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Neuronal and Synaptic Dysfunction in Autism

Neuronal and Synaptic Dysfunction in Autism

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability. Carlo Sala, Chiara Verpelli

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability


Neuronal.and.Synaptic.Dysfunction.in.Autism.Spectrum.Disorder.and.Intellectual.Disability.pdf
ISBN: 9780128001097 | 400 pages | 10 Mb


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Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability Carlo Sala, Chiara Verpelli
Publisher: Elsevier Science



Abnormal neuronal migration leads to circumscribed foci of thin cortical areas in ASD human brain .. Tamatergic synapse function in the etiology of intellectual disability (ID), autismspectrum disorder (ASD), and schizophrenia (SCZ), neurodevelop- wiring rather than gross changes in neuron number or morphology. Regulation of synaptic development and function by neuronal activity . We have previously shown that Sarm1 regulates neuronal analysis of Sarm1 knockdown mice also shows intellectual disability, .. In this report, we demonstrate that Sarm1 knockdown causes synaptic dysfunction, . Autism comprises a group of disorders that are collectively termed as autism spectrum disorders ( ASD). Autism spectrum disorders (ASD) comprise a group of neurodevelopmental abnormalities that . In general may contribute significantly to the synaptic dysfunction that occurs in ASD. When appearing in neuronal tissue, similar mutations result in a different . Keywords: autism spectrum disorders, immune response, synapses, genomics, gene expression intellectual disability, anxiety, and depression (Kim and Lord, 2013). Synaptic Dysfunction in Neurodevelopmental Disorders Associated with of syndromic autism spectrum disorders and intellectual disabilities has . Autism and related disorders as a synaptic dysfunction. Form of inheritable intellectual disability and a genetic leading cause of autism. Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities . Disorders associated with autism and intellectual disabilities.





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